| ncRNA name | HIF-1α siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (HREC) and human dermal microvascular endothelial cells (HDMEC) |
| Methods | confocal immunofluorescence, siRNA transfection, qPCR, Western blot, flow cytometry |
| Expression pattern | associated |
| Functional description | Knockdown of HIF-1α expression by siRNA in the HREC and HDMEC inhibited Robo4 expression in mRNA and protein level, while overexpressed HIF-1α increased Robo4 mRNA and protein expression. Silencing HIF-1α in endothelial cells under hypoxic conditions inhibited cell invasion and proliferation |
| PubMed ID | 26066603 |
| Year | 2015 |
| Title | Investigation of the Regulation of Roundabout4 by Hypoxia-Inducible Factor-1α in Microvascular Endothelial Cells. |
| Drug-related ncRNA | NO |
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